Prepulse inhibition and P50 suppression: Commonalities and dissociations
نویسندگان
چکیده
منابع مشابه
The effects of imipramine on P50 suppression, prepulse inhibition and habituation of the startle response in humans.
Schizophrenic patients exhibit impairments in filtering of sensory information, as can be assessed by use of prepulse inhibition (PPI) of the acoustic startle response and P50 suppression paradigms. In the treatment of negative symptoms or depressive syndromes during the course of schizophrenia antidepressants are often combined with antipsychotic medication. However, antidepressants increase m...
متن کاملPrepulse-elicited startle in prepulse inhibition.
BACKGROUND Prepulse inhibition (PPI) has become a major experimental paradigm in the study of psychiatric disorders. In this study, a potential confound in measurement and interpretation of PPI, namely startle reactions to so-called "nonstartling" prepulses, was examined. METHODS Prepulses of 80, 85, and 90 dB(A) were presented on their own or followed by a pulse of 115 dB(A) (lead interval: ...
متن کاملPrepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings.
BACKGROUND Deficits in schizophrenia patients and their first-degree relatives have been reported in prepulse inhibition (PPI), a phenomenon that measures an early stage of information processing (sensorimotor gating). It is less clear whether these information processing deficits extend to prepulse facilitation (PPF), which measures a later stage of generalized alerting or orienting. METHODS...
متن کاملReflex excitability regulates prepulse inhibition.
Presentation of a weak stimulus, a prepulse, before a reflex-evoking stimulus decreases the amplitude of the reflex response relative to reflex amplitude evoked without a preceding prepulse. For example, presenting a brief tone before a trigeminal blink-eliciting stimulus significantly reduces reflex blink amplitude. A common explanation of such data are that sensory processing of the prepulse ...
متن کاملRelationship between P50 suppression and the cortical silent period.
Deficient inhibitory neurotransmission has been demonstrated in schizophrenia through electroencephalography (e.g. P50 suppression) and transcranial magnetic stimulation (e.g. short-interval cortical inhibition and the cortical silent period). It is not known whether these inhibitory paradigms are related despite evidence suggesting that both are coordinated through gamma-aminobutyric acid inhi...
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ژورنال
عنوان ژورنال: Psychiatry Research
سال: 2006
ISSN: 0165-1781
DOI: 10.1016/j.psychres.2005.11.002